What Do Human Trials Say About SARMs?

SARMs (Selective Androgen Receptor Modulators) are creating a buzz in the fitness and bodybuilding world—and for good reason. They offer the potential for serious muscle gains, enhanced performance, and even therapeutic benefits, all while avoiding many of the unwanted side effects associated with traditional anabolic steroids.

But what does the science say? Are SARMs the real deal? Let’s take a look at what human trials have revealed so far.

What Are SARMs, and Why Are They Different?

If you’ve been researching muscle-building supplements, you’ve probably come across SARMs. These compounds work by selectively binding to androgen receptors in muscle and bone tissue, triggering growth without affecting other parts of the body as traditional steroids do. This selectivity is what makes SARMs so exciting—because they can promote muscle gains with fewer side effects.

Think of them as a more refined, science-backed approach to muscle building. While steroids flood the entire body with androgens, SARMs target only the areas you actually want to enhance—your muscles and bones.

How Do SARMs Compare to Steroids?

Feature	SARMs	Anabolic Steroids
Tissue Selectivity	Targets muscle & bone only	Affects multiple organs
Risk of Side Effects	Lower when used correctly	High
Legal Status	Research chemical (varies)	Controlled substance
Hormonal Impact	Mild, reversible suppression	Significant hormonal disruption

While SARMs aren’t without risks, they’re generally seen as a safer, more controlled option for those looking to gain muscle and improve performance.

While research is still ongoing, clinical studies have been promising. Human trials have tested SARMs like Ostarine, Ligandrol, and Testolone, and the results suggest they could be a game-changer for muscle growth, bone density, and even medical applications like combating muscle wasting in older adults.

Ostarine (Enobosarm)

One of the most studied SARMs.
It has been shown to increase lean muscle mass and improve physical performance.
In a phase 2 study, ostarine (also known as enobosarm) increased lean body mass, decreased fat mass, and modestly improved insulin sensitivity.
Potential use in treating muscle-wasting diseases.
Minimal side effects were reported in trials.

Ligandrol (LGD-4033)

Known for its ability to enhance skeletal muscle mass and bone strength.
Clinical trials found significant muscle gains with just small doses.
Some SARMs have shown potential in preventing bone loss in animal models of osteoporosis, suggesting they may have applications in maintaining bone health.
Few reported side effects, but liver function should be monitored.

Testolone (RAD-140)

Designed to boost muscle size and strength.
Early trials suggest it could be one of the most potent SARMs available.
Still under research, but it shows exciting muscle-building potential.

Human trials have shown that SARMs can increase lean body mass in both healthy volunteers and patients with chronic diseases.

Clinical trials have shown that SARMs can improve muscle strength, particularly in men with chronic obstructive pulmonary disease (COPD). In a trial involving COPD patients, a SARM called GSK2881078 demonstrated an acceptable safety profile and increased lean body mass.

In clinical settings, SARMs have consistently demonstrated muscle-building benefits, with studies showing an increase in lean body mass and improvements in physical function.

And the best part? Users often report feeling stronger and more energised without the bloating, aggression, or other common steroid-related issues.

The Benefits of SARMs Beyond Bodybuilding

While SARMs are widely known for their muscle-building potential, they also show promise in other areas:

Fat Loss: SARMs can help with recomposition, meaning you can build muscle while shedding fat.
Bone Health: Increased bone density makes SARMs attractive for those concerned with osteoporosis.
Enhanced Recovery: Users report faster recovery from workouts and injuries.
Injury Prevention: Stronger muscles and bones mean a lower risk of injuries.
Potential Medical Use: SARMs are being studied for their potential in treating muscle-wasting diseases and other chronic conditions.
SARMs have been found to activate the androgen receptor in both muscle and bone tissues, potentially offering benefits for muscle and bone health without significant systemic side effects.
In breast cancer research, some SARMs have shown promise in inhibiting cancer growth, particularly in patients with androgen receptor-positive tumors.

Are SARMs Safe? Understanding the Risks

The big question: Are SARMs safe?

Like any performance enhancer, SARMs do come with potential risks, particularly if misused. While they have fewer side effects than steroids, some users report mild testosterone suppression, liver strain, or slight cardiovascular effects. However, these risks tend to be dose-dependent and reversible with proper use.

Common Side Effects of SARMs:

Mild Testosterone Suppression: This can be managed with post-cycle therapy (PCT).
Temporary Liver Strain: This can be minimised by avoiding excessive doses and combining with liver-supporting supplements.
Water Retention: Rare, but can occur in some users.
Mild Fatigue or Headaches: Usually temporary and dose-related.

The key takeaway? Stick to recommended doses, take post-cycle therapy (PCT) if needed, and choose high-quality SARMs from a trusted source.

How to Use SARMs Safely and Effectively

If you’re considering SARMs, following best practices will ensure you get the most out of them while minimising risks.

Start with a Low Dose

Your body needs time to adjust, so starting with a low dose and gradually increasing is the best approach.

Choose the Right SARM for Your Goal

For bulking: Ligandrol (LGD-4033) and Testolone (RAD-140) are top choices.
For cutting/recomping: Ostarine (MK-2866) and Andarine (S4) can help shed fat while maintaining muscle.

Stick to Recommended Cycle Lengths

Using SARMs for too long can increase the risk of side effects. Most cycles last 8-12 weeks, followed by a break and post-cycle therapy (if needed).

Take Post-Cycle Therapy (PCT) If Necessary

Some SARMs can cause mild testosterone suppression. If you notice any symptoms, a short PCT can help restore hormone balance.

Buy from a Trusted Source

Not all SARMs are created equal. Always buy from a reputable supplier like UK SARMs to avoid bunk or dangerous products.

The Future of SARMs

SARMs are still being studied for potential therapeutic applications beyond bodybuilding. Researchers are exploring their use in treating conditions like:

Muscle-wasting diseases (e.g., cancer-related muscle loss)
Osteoporosis and bone density issues
Age-related muscle decline

As research advances, we’re likely to see SARMs become even more refined, with improved safety profiles and wider medical applications. For now, they remain one of the most exciting innovations in performance enhancement.

Ready to Buy SARMs Safely?

When it comes to buying SARMs, quality matters. UK SARMs is a trusted supplier offering high-quality, lab-tested SARMs to ensure safety and effectiveness. With rigorous testing and transparency, they provide products you can rely on.

Whether you’re a seasoned athlete, a bodybuilder, or simply looking to optimise your physique, UK SARMs has the right products to help you achieve your goals.

✅ 100% lab-tested for purity

✅ Trusted by athletes and bodybuilders

✅ Reliable and safe shipping

To buy SARMs safely and get the best results, head to UK SARMs today!

Which SARM is the best for muscle gain?

It can be difficult to determine which SARMs are best for lean muscle building because different body types respond differently to them. Almost all SARMs boost muscle gain, but some have a stronger effect than others.

Top-tier SARMs for muscle gain include:

Test RAD-140
Ibutamoren MK-677
Ostarine MK-2866

Compared to some other brands, they also offer really good performance. RAD-140, Ostarine, and MK-677 are well-known for boosting muscle growth explosively and making gaining muscle much easier.

If you want to gain a lot of muscle quickly, consider using one of the above SARMs.

Do SARMs have side effects?

SARMs’ side effects are generally fewer and less serious than those of anabolic steroids. Still, using SARMs supplement products does have a small risk of complications.

Some side effects that have been reported include:

Diarrhoea
Headaches
Hypertension
Heart disease
Aggression
Acne

It is important to remember that the severity and presence of a side effect will likely depend on both dosage and the specific SARM taken.

Why should I use SARMs?

Burning fat
Bulking or cutting
Improving performance
Decreased recovery time
Building lean body mass
Increasing bone density

What are SARMs?

SARMs, or selective androgen receptor modulators, are relatively new drugs that attach to your body’s androgen receptors, triggering changes in your DNA, which in turn increases your muscles’ ability to grow. Unlike steroids, they target specific types of tissues and don’t come with side effects like breast growth in males.

They combat muscle loss caused by age, osteoporosis, disease, and building muscle and bone. Due to their ability to improve strength with fewer side effects than steroids, dietary supplement brands have started selling them to athletes.

Because they’re anabolic agents that enhance performance, SARMs are on the World Anti-Doping Agency’s list of prohibited substances.

How long should I wait between SARM cycles?

SARM cycles are intense, and you need to recover between them to ensure you don’t end up with long-term damage.

On average, SARM cycles last 8-12 weeks, and Post Cycle Therapy lasts 2-4 weeks. So if you wanted to start another cycle, it would have to be after the PCT. When your hormone and testosterone levels are back where they should be, you can begin another SARMs cycle.

You need to keep your body healthy and safe when cycling SARMs and building muscle to keep building and growing it. Take the next step only when you’re ready.