PT141 | Research-Grade Peptide for Neuroendocrine and Sexual Function Studies

Explore the powerful applications of PT141, a high-purity peptide widely used in research on neuroendocrine function, sexual behavior, and melanocortin receptor pathways. Manufactured to rigorous quality standards and supported by a strong foundation of scientific literature, PT141 is an essential tool in laboratories investigating central nervous system signaling, sexual arousal mechanisms, and receptor pharmacology.

What is PT141?

PT141, also known by its chemical name Bremelanotide, is a synthetic peptide analog of α-MSH (alpha-melanocyte-stimulating hormone). It was developed to target melanocortin receptors in the brain, particularly MC3R and MC4R, which play a role in regulating libido, mood, and energy balance. Unlike other compounds that act through vascular pathways, PT141 acts directly on the central nervous system, making it a unique agent in neurobehavioral and sexual health research.

Originally derived from Melanotan II, it has gained attention for its receptor specificity and central mode of action. It is currently the only compound of its kind that has received FDA approval (under the name Vyleesi) for the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women — further highlighting its importance as a research molecule.

Product Specifications

• Product Name: PT141

• Chemical Name: Bremelanotide

• Sequence: Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys)-OH

• Molecular Formula: C50H68N14O10

• Molecular Weight: 1025.2 g/mol

• Form: Lyophilized powder

• Purity: ≥98% (HPLC)

• Volume: Customizable — typically supplied in 10mg vials

• Intended Use: Laboratory research only; not for human consumption

Our PT141 is synthesized and tested in ISO-certified, GMP-compliant facilities. Every batch is subjected to strict quality control including mass spectrometry, HPLC purity verification, and sterility screening (if applicable).

✅ PT141 Chemical Identifiers

• PubChem CID: 9941379

• UNII (FDA): 6Y24O4F92S

Scientific Research & Mechanism of Action

PT141 works by activating melanocortin receptors in the brain, particularly MC3R and MC4R. These receptors are involved in sexual arousal, appetite regulation, stress response, and energy homeostasis. When PT141 binds to these receptors, it initiates a cascade of neurotransmitter responses that influence behavior, motivation, and mood — particularly via dopaminergic and hypothalamic pathways.

Key areas of research interest include:

• Hypoactive Sexual Desire Models

• Neuroendocrine Signaling Studies

• Melanocortin Receptor Pharmacodynamics

• Dopaminergic Activation and Reward Response

• Central Nervous System Modulation

Unlike PDE5 inhibitors that require peripheral arousal signals (like nitric oxide), PT141 has been shown in preclinical models to influence sexual motivation directly via neural circuits, making it a unique subject of CNS-focused sexual function research.

Benefits in Research Settings

• ✅ Targets central nervous system rather than vascular pathways

• ✅ Offers unique MC4R and MC3R receptor selectivity

• ✅ Highly stable in lyophilized form

• ✅ Rapid onset and short half-life make it suitable for controlled dosing models

• ✅ Supports studies on stress, appetite, and reward behavior in addition to sexual function

PT141’s profile makes it especially valuable for researchers studying multi-system interaction between hormonal, neurological, and behavioral pathways.

Storage and Reconstitution

• Storage (lyophilized): -20°C or colder

• After reconstitution: Store at 2–8°C and use within 30 days

• Solvents: Sterile bacteriostatic water (BAC water) or sterile saline

• Shelf Life: 24 months from production (lyophilized)

Safety and Handling

PT141 is supplied for laboratory research use only. It is not approved for human or veterinary use, drug development, or diagnostic procedures. Handle under appropriate safety conditions, and dispose of according to local chemical waste guidelines.

How to Use 

PT141 is commonly reconstituted in sterile water for injection (SWFI) or bacteriostatic water and administered subcutaneously in controlled animal studies. Dosage and protocol will vary based on study design, species, and purpose. Always consult appropriate institutional guidelines and ensure protocols are approved by relevant ethical boards (e.g., IACUC, IRB).

Legal and Compliance Notice

PT141 is not a dietary supplement or drug. It is offered strictly for in vitro or in vivo laboratory research purposes only. Sale is conditioned on the customer’s agreement that it will not be used for any other purpose, including but not limited to human or veterinary use, or resale.

Why Buy From Us?

• 📦 Tamper-evident, sterile packaging

• 🧪 Full Certificates of Analysis (COAs) provided

• 🌐 Global shipping with cold-chain options

• 🛡️ Trusted by universities, clinics, and private labs

Order Today

Equip your lab with research-grade PT141 and contribute to the expanding field of neurobehavioral science and sexual health research. Our peptide is guaranteed to meet or exceed purity and consistency standards, with batch-level traceability and expert customer support.

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