TB500 

Peptide for Advanced Tissue Recovery and Regeneration – Research Use Only

Contains:

1x TB500 5mg Vial

1x Bacteriostatic Water for Injection (with Benzyl Alcohol)

Overview

TB500 is a synthetic peptide derived from the naturally occurring protein Thymosin Beta-4, which plays a critical role in cellular repair and regeneration. Engineered for stability and efficiency, TB500 contains the active region of Thymosin Beta-4, allowing it to replicate its biological activity while offering advantages in shelf-life, ease of use, and research viability.

Each vial contains 5mg of TB500 in lyophilized powder form, suitable for reconstitution under sterile laboratory conditions. This compound is intended strictly for laboratory research and is not for human or veterinary use.

Scientific Background

Thymosin Beta-4 is found in virtually all human and animal cells and is particularly concentrated in sites of tissue injury. Its role in wound healing, inflammation reduction, and angiogenesis (formation of new blood vessels) has made it a focus of biomedical research.

TB500 is a smaller, synthetically optimized fragment of this larger peptide. By isolating the part of the molecule responsible for actin regulation, TB500 provides a more targeted and manageable compound for laboratory study. Its mechanisms of action are believed to center on enhanced cellular migration, modulation of inflammatory response, and stimulation of tissue regeneration.

Mechanism of Action

TB500 primarily works by promoting the polymerization of actin, a protein crucial to the cytoskeleton of all cells. By regulating actin activity, TB500 assists in cell movement and structural repair. This actin-binding property makes TB500 particularly relevant in models of wound healing and organ regeneration.

Other observed mechanisms in animal and in vitro models include:

• Enhanced migration of stem cells and repair cells to damaged tissues
• Stimulation of angiogenesis, improving blood supply in injured areas
• Downregulation of inflammatory cytokines, contributing to faster recovery
• Support for nerve and muscle cell regeneration in various tissue types

TB500 has also demonstrated potential in models of ocular damage, cardiovascular repair, and soft-tissue injuries, making it a peptide of growing interest across multiple fields of study.

Research Applications

While not approved for medical use, TB500 has been widely explored in preclinical research for its role in healing and regeneration. Below are some of the most common applications observed in laboratory settings:

1. Musculoskeletal Repair

In animal studies, TB500 has been shown to accelerate the recovery of skeletal muscle, tendons, and ligaments following injury. Its ability to stimulate satellite cell activation and reduce fibrotic tissue buildup has made it an appealing peptide for orthopedic and sports-related injury research.

2. Cardiovascular Regeneration

TB500 is being evaluated in cardiac models for its angiogenic and anti-fibrotic properties. By increasing vascular endothelial growth factor (VEGF) expression and promoting new blood vessel formation, it may support healing in post-myocardial infarction environments.

3. Wound Healing and Skin Recovery

One of the earliest uses of TB500 in research involved dermal wound healing. Studies have noted accelerated epithelialization and collagen deposition in skin injury models, even under diabetic or ischemic conditions.

4. Joint and Tendon Health

In arthritis models, TB500 has been found to reduce swelling, improve flexibility, and slow the progression of inflammatory degradation. It’s also being tested in equine models for tendonitis and ligament damage with promising results.

5. Nervous System Repair

Emerging studies have indicated potential neuroregenerative effects. TB500 may support axonal regrowth and remyelination, suggesting further study in spinal cord injury or peripheral nerve damage models could be warranted.

Product Details

• Compound: TB500 (Thymosin Beta-4 fragment)
• Molecular Formula: C212H350N56O78S
• Molecular Weight: ~4963.5 g/mol
• Unit Size: 5mg
• Appearance: White lyophilized powder
• Purity: ≥99% (HPLC verified)
• Packaging: Sterile, light-resistant 2ml vial
• Storage (unreconstituted): Store at -20°C
• Storage (reconstituted): Refrigerate at 2–8°C and use within 20 days
• Solubility: Soluble in bacteriostatic or sterile water

Verified Chemical Identifiers for TB‑500

• CAS Number: 885340‑08‑9

• PubChem CID: 62707662

• UNII: QHK6Z47GTG

Handling & Reconstitution

TB500 is provided in lyophilized form and must be reconstituted prior to research use. It is recommended to use bacteriostatic water for injection to maintain sterility. Gently swirl the vial until fully dissolved—do not shake vigorously.

Always use aseptic techniques and proper laboratory safety protocols when handling peptides.

Lab Use Only – Not for Human Consumption

This compound is offered strictly for laboratory research use only. It is not intended for use in humans, animals, or any type of therapeutic or diagnostic application. Any improper use is strictly prohibited. By purchasing, you confirm that you are qualified to handle this compound in accordance with relevant research guidelines and safety standards.

Comparison: TB500 vs Full-Length Thymosin Beta-4

TB500 is favoured in research environments for its ease of storage, dosing flexibility, and reliable performance under varied conditions.

Storage Guidelines

• Keep unreconstituted vials in a dark, frozen environment (-20°C) to ensure stability.
• After reconstitution, store the solution in the refrigerator (2–8°C).
• Avoid repeated freeze-thaw cycles to prevent degradation.
• Use within 20 days after mixing for best results.

Purity & Quality Assurance

Our TB500 is manufactured in GMP-compliant laboratories and independently third-party tested. Each batch is supplied with a full Certificate of Analysis, verifying:

• Amino acid sequence
• Peptide mass (MS)
• Purity (HPLC)
• Solubility
• pH and sterility

We are committed to providing researchers with consistent, reliable compounds supported by transparent documentation and professional support.

Frequently Asked Questions

Q: Is this product legal?
A: TB500 is legal to purchase for laboratory research purposes. It is not approved for human consumption or medical treatment.

Q: How long does it last after reconstitution?
A: When stored properly in a sterile vial in refrigeration, it is best used within 20 days.

Q: Do you provide documentation?
A: Yes. Each order includes a Certificate of Analysis and lab-grade reference data for your records.

Q: Can TB500 be shipped internationally?
A: We ship to most countries, but it’s your responsibility to comply with local regulations regarding peptides and research chemicals.

Why Choose Us?

• ✔️ Research-grade quality backed by documentation
• ✔️ Tamper-proof packaging for product integrity
• ✔️ Responsive support from industry-experienced staff
• ✔️ Discreet shipping worldwide
• ✔️ Bulk pricing available for institutions and labs

Order TB500 (5mg) – Research-Grade Peptide

TB500 continues to be one of the most versatile peptides studied for tissue repair, wound healing, and anti-inflammatory research. With reliable quality, detailed documentation, and professional service, we support your lab’s goals every step of the way.

Combine with BPC157 for added benefits: https://www.uksarms.com/product/bpc-157-body-protection-compound-157/