IGF-1 LR3 is a synthetic analogue of insulin-like growth factor 1 (IGF-1). Its structure differs from IGF-1 in that it has 13 additional amino acids at the N-terminus, making it a total of 83 amino acids long. This modification enhances its biological activity, resulting in a higher affinity for the IGF-1 receptor and a lower affinity for IGF-binding proteins compared to endogenous IGF-1. This lower affinity for IGF-binding proteins allows IGF-1 LR3 to remain in its active, unbound form, where it can bind to IGF-1 receptors.
Mechanism of Action
IGF-1 LR3 and IGF-1 both bind to IGF-1 receptors, the stimulation of which activates pathways, including PI3K/AKT and MAPK, to bring about the following effects:
- Promotion of glucose uptake and subsequent utilisation
- Increase in energy production in cells
- Enhancement of glycolysis
- Increased protein and lipid synthesis
- Coordination of nutrient uptake
- Increase in cell proliferation and differentiation
- Changes in gene expression that support cell cycle progression and tissue growth.
The combination of these activities helps to support cell growth, cell survival, and metabolic health, meaning IGF-1 LR3 could be a useful therapeutic compound.
Therapeutic Potential
Due to its high affinity for the IGF-1 receptor and the benefits that activation of this receptor can provide, it has been investigated for its ability to treat:
- Wounds and Injuries: IGF-1 LR3 supports the regeneration of tendons and nerves after injury, potentially speeding recovery and reducing scar formation. It does this by promoting angiogenesis, reducing inflammation, and accelerating tissue repair.
- Neurodegenerative Disease: It promotes neurogenesis and cell survival, possibly protecting against neurodegeneration. It may also help preserve motor function.
- Nerve-Related Problems: Since IGF-1 LR3 supports neuronal survival, growth and function, it can help nerves to regenerate after damage, assisting recovery from peripheral nerve injuries. Because IGF-1 signalling is involved in the management of neuropathic pain, IGF-1 LR3 may be useful in the treatment of nerve pain.
- Obesity and Metabolic Disorders: It can regulate adipose tissue metabolism, improve insulin sensitivity and lipid profiles, and enhance glucose metabolism, so it may prove useful in the treatment of metabolic dysfunction.
- Muscle Wasting Conditions: It can counteract muscle wastage by stimulating the synthesis of protein, which supports the growth and regeneration of muscle. It stimulates the proliferation of muscle satellite cells, which are important for muscle regeneration and repair. IGF-1 LR3 also inhibits protein breakdown and suppresses the expression of genes that drive muscle atrophy.
- Cardiovascular Related Issues: It can stimulate the growth and survival of heart muscle cells, promoting cardiac development. Because IGF-1 is involved in the heart’s response to injury, improves contractility, and reduces cardiac fibrosis, it could be used to improve heart function after myocardial infarction.
Safety
Although many animal studies have looked into the potential therapeutic benefits of IGF-1 LR3, human studies are still lacking. Because of the pathways it activates, there is some concern that it may drive the growth of existing cancer cells.
Data Sheet
| Application | Research on tissue repair, growth, neuroprotection, and metabolism |
| CAS Number | 946870-92-4 |
| Molar Mass | 9,118 Da |
| Sequence | MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA |
| Chemical Formula | C400H625N111O115S9 |
| Synonyms | Long Arginine 3-IGF-1, LR3 IGF-1, IGF-1 LR3 |
| Storage | Keep refrigerated at 2-8°C until use. For long-term storage, keep at -20°C. |
| Reconstitution | Reconstitute in sterile water. The reconstituted solution is stable for up to one week at 2-8°C. |
| Organoleptic Profile | White to off-white lyophilised powder |
| Physical Form | Solid |
Conclusion
IGF-1 LR3 activates IGF-1 receptors to produce several potentially beneficial effects, most notably, an increase in cell growth and survival, and metabolic regulation. What we know about the activity of this compound comes mostly from in vitro and animal studies. Human studies will help to further elucidate its therapeutic potential.
Henry –
I’ve been using IGF-1 DES 5 mg for targeted muscle growth and recovery, and the results have been excellent. Within days of continuous use, I noticed increased muscle fullness and faster recovery after intense workouts. It’s also helped with overall performance and endurance. The gains are clean and lean — no water retention or bloating. This peptide is a great addition to any serious athlete’s stack. Definitely worth it!
Mike –
Top-quality product, as always, from UK SARMS Suppliers.
Simon Swift –
Trained chest and back. About 30 minutes later, I can’t believe the strength pump. All went up.
Louise March –
I’ve been using IGF-1 DES 5 mg for targeted muscle growth and recovery, and the results have been excellent. Within days of localized injections. Highly recommend.
Jay walker –
I noticed increased muscle fullness and faster recovery after intense workouts few days after use. It’s also helped with overall performance and endurance. The gains are clean and lean — no water retention or bloating.
Hanna –
This peptide is a great addition to any serious athlete’s stack. Definitely worth it!
Brandon L –
Love all supplies for gym from UK SARMs
Robin Winiarczyk –
I’ve been in bodybuilding for over 6 years and have tried all sorts of supplements, but IGF-1 DES (1,3) honestly surprised me. What stood out most is how targeted the growth feels. I inject it directly into the muscle I’m training, and within a few weeks, I noticed better fullness and definition in those specific areas — especially my delts and biceps.
Rolando Medina –
The recovery time between workouts has also shortened drastically. It feels like my muscles are repairing themselves faster than ever before.
Dwayne Connelly –
I was stuck at the same weight for months, no matter how hard I trained. After I started using IGF-1 DES, things changed fast. My strength went up, and I began to see visible changes in my muscle density.
BOULARD –
The pump I get during workouts is next level. Plus, my recovery time has dropped significantly — I’m no longer sore for days after a tough session. It’s like my body finally started responding again.
Sherine Kamal –
As someone who trains five days a week, recovery is a big deal for me. With IGF-1 DES, I can hit the gym harder and still feel fresh the next day. I’ve also noticed I’m getting leaner — my midsection is more defined without losing muscle mass.
Simon Griffiths –
I love that it doesn’t just help with size but also helps keep my body composition tight. Definitely staying on my list of essentials.
John Batres –
One of my biggest struggles has been achieving symmetry — my left bicep was always smaller. After a month of using it, the difference is nearly gone. I can target weaker areas and bring them up to match the rest of my physique. I’ve never seen results this balanced before.
Chris –
I recently started using IGF-1 DES after a shoulder strain that was slowing down my training. Within two weeks, I could already tell my shoulder was healing faster. The muscle feels stronger, and the pain has reduced a lot. Beyond the recovery benefits, I’ve noticed better muscle tone and energy overall. It’s like my body is in a constant state of repair and improvement.
Tim Craton –
I didn’t expect results this quickly. Within the first few weeks of using IGF-1, my muscles started feeling denser and stronger.
Vanessa Kountz –
The pumps are intense, and the visual change in muscle fullness is real. I also appreciate that it doesn’t make me feel bloated like some other growth products. Everything feels clean and natural.
Ryota Watanabe –
I compete in fitness events, so muscle recovery and control over growth areas are key. IGF-1 DES has given me both. I can train specific muscle groups harder without worrying about overtraining, because recovery happens faster.
Konrad –
My endurance has improved, and I’ve been able to stay lean while still adding noticeable size. It’s easily one of the best performance aids I’ve ever used.
J. Batres –
After being stuck at the same muscle size for months, IGF-1 changed everything. Within three weeks, I started noticing fuller biceps and better definition across my chest. By week eight, I’d gained visible size without fat gain. Recovery between workouts feels twice as fast, and I’m lifting heavier with confidence. This peptide really does what it says — targeted, potent, and fast-acting.
Tim Craton –
My left arm was always lagging behind my right. This peptide helped me fix that. Injecting it directly into the weaker bicep made a real difference — the muscle finally caught up in both size and shape.
Vanessa Kountz –
The symmetry across my upper body has improved a lot, and the muscle pump during workouts is insane. I’ve never had such focused results from any other peptide.
Hady Nassar –
I wanted to stay lean while adding some definition, and this did exactly that. My midsection is tighter, and my muscles feel more dense without looking bulky. I’ve also noticed my energy during workouts is more consistent, and post-training soreness doesn’t last nearly as long. It’s the perfect balance between recovery and lean muscle growth.
Jule –
After a shoulder strain, I started using IGF-1 DES on a friend’s recommendation. Within two weeks, my mobility improved, and the pain subsided. It sped up the healing process noticeably. On top of that, my shoulder muscles actually look fuller now. It’s not just a recovery tool — it enhances growth in all the right ways.
Andrew J. Schuler –
Incredible strength and recovery boost
DennisL Merritt –
I train heavy five days a week, and with IGF-1, I can train back-to-back days without soreness holding me back. My muscles look and feel tighter, and my endurance has improved. It’s like my body’s repair switch is permanently turned on.
Aleksandar –
Honestly, I didn’t expect to see results so soon. Within the first few weeks, my chest and triceps looked fuller, and I was already lifting heavier. The product kicks in quickly — you feel stronger, recover faster, and the muscle tone becomes more visible. It definitely lives up to the hype.
Felipe –
Training at a competitive level means recovery is everything. IGF-1 has become a core part of my routine. It allows me to push harder without feeling overtrained. My legs feel stronger, my body leans out faster, and my energy levels have gone up. It’s rare to find something that works this efficiently — I’m genuinely impressed.
Marcin (verified owner) –
All those reviews are for IGF-1 DES. That’s different compaund from IGF-1 LR3..
Second one it’s much better as a peptide.
And that one which you have in stock. I hope I just ordered it. Can’t rate it at the moment still waiting for a shipment.