TB500
Peptide for Advanced Tissue Recovery and Regeneration—Research Use Only
Contains:
1x TB500 5 mg Vial
1x Bacteriostatic Water for Injection (with Benzyl Alcohol)
Overview
TB500 is a synthetic peptide derived from the naturally occurring protein Thymosin Beta-4, which plays a critical role in cellular repair and regeneration. Engineered for stability and efficiency, TB500 contains the active region of Thymosin Beta-4, allowing it to replicate its biological activity while offering advantages in shelf life, ease of use, and research viability.
Each vial contains 5 mg of TB500 in lyophilized powder form, suitable for reconstitution under sterile laboratory conditions. This compound is intended strictly for laboratory research and is not for human or veterinary use.
Scientific Background
Thymosin Beta-4 is found in virtually all human and animal cells and is particularly concentrated in sites of tissue injury. Its role in wound healing, inflammation reduction, and angiogenesis (formation of new blood vessels) has made it a focus of biomedical research.
TB500 is a smaller, synthetically optimized fragment of this larger peptide. By isolating the part of the molecule responsible for actin regulation, TB500 provides a more targeted and manageable compound for laboratory study. Its mechanisms of action are believed to center on enhanced cellular migration, modulation of inflammatory response, and stimulation of tissue regeneration.
Mechanism of Action
TB500 primarily works by promoting the polymerization of actin, a protein crucial to the cytoskeleton of all cells. By regulating actin activity, TB500 assists in cell movement and structural repair. This actin-binding property makes TB500 particularly relevant in models of wound healing and organ regeneration.
Other observed mechanisms in animal and in vitro models include:
- Enhanced migration of stem cells and repair cells to damaged tissues
- Stimulation of angiogenesis, improving the blood supply in injured areas
- Downregulation of inflammatory cytokines, contributing to faster recovery
- Support for nerve and muscle cell regeneration in various tissue types
TB500 has also demonstrated potential in models of ocular damage, cardiovascular repair, and soft-tissue injuries, making it a peptide of growing interest across multiple fields of study.
Research Applications
While not approved for medical use, TB500 has been widely explored in preclinical research for its role in healing and regeneration. Below are some of the most common applications observed in laboratory settings:
1. Musculoskeletal Repair
In animal studies, TB500 has been shown to accelerate the recovery of skeletal muscle, tendons, and ligaments following injury. Its ability to stimulate satellite cell activation and reduce fibrotic tissue buildup has made it an appealing peptide for orthopedic and sports-related injury research.
2. Cardiovascular Regeneration
TB500 is being evaluated in cardiac models for its angiogenic and anti-fibrotic properties. By increasing vascular endothelial growth factor (VEGF) expression and promoting new blood vessel formation, it may support healing in post-myocardial infarction environments.
3. Wound Healing and Skin Recovery
One of the earliest uses of TB500 in research involved dermal wound healing. Studies have noted accelerated epithelialization and collagen deposition in skin injury models, even under diabetic or ischemic conditions.
4. Joint and Tendon Health
In arthritis models, TB500 has been found to reduce swelling, improve flexibility, and slow the progression of inflammatory degradation. It’s also being tested in equine models for tendonitis and ligament damage with promising results.
5. Nervous System Repair
Emerging studies have indicated potential neuroregenerative effects. TB500 may support axonal regrowth and remyelination, suggesting further study in spinal cord injury or peripheral nerve damage models could be warranted.
Product Details
- Compound: TB500 (Thymosin Beta-4 fragment)
- Molecular Formula: C212H350N56O78S
- Molecular Weight: ~4963.5 g/mol
- Unit Size: 5 mg
- Appearance: White lyophilized powder
- Purity: ≥99% (HPLC verified)
- Packaging: Sterile, light-resistant ml vial
- Storage (unreconstituted): Store at -20°C
- Storage (reconstituted): Refrigerate at 2–8°C and use within 20 days
- Solubility: Soluble in bacteriostatic or sterile water
Verified Chemical Identifiers for TB‑500
- CAS Number: 885340‑08‑9
- PubChem CID: 62707662
- UNII: QHK6Z47GTG
Handling & Reconstitution
TB500 is provided in lyophilized form and must be reconstituted prior to research use. It is recommended to use bacteriostatic water for injection to maintain sterility. Gently swirl the vial until fully dissolved—do not shake vigorously.
Always use aseptic techniques and proper laboratory safety protocols when handling peptides.
Lab Use Only: Not for Human Consumption
This compound is offered strictly for laboratory research use only. It is not intended for use in humans, animals, or any type of therapeutic or diagnostic application. Any improper use is strictly prohibited. By purchasing, you confirm that you are qualified to handle this compound in accordance with relevant research guidelines and safety standards.
Comparison: TB500 vs Full-Length Thymosin Beta-4
| Feature | TB500 | Thymosin Beta-4 |
|---|---|---|
| Molecular Size | 17 amino acids | 43 amino acids |
| Research Stability | High | Moderate |
| Focused Action | Yes (targeted actin segment) | Broader biological activity |
| Cost Efficiency | More affordable per dose | Higher cost per unit |
| Common in Research Models | Yes | Less common due to instability |
TB500 is favoured in research environments for its ease of storage, dosing flexibility, and reliable performance under varied conditions.
Storage Guidelines
- Keep unreconstituted vials in a dark, frozen environment (-20°C) to ensure stability.
- After reconstitution, store the solution in the refrigerator (2–8°C).
- Avoid repeated freeze-thaw cycles to prevent degradation.
- Use within 20 days after mixing for best results.
Purity & Quality Assurance
Our TB500 is manufactured in GMP-compliant laboratories and independently third-party tested. Each batch is supplied with a full Certificate of Analysis, verifying:
- Amino acid sequence
- Peptide mass (MS)
- Purity (HPLC)
- Solubility
- pH and sterility
We are committed to providing researchers with consistent, reliable compounds supported by transparent documentation and professional support.
Frequently Asked Questions
Q: Is this product legal?
A: TB500 is legal to purchase for laboratory research purposes. It is not approved for human consumption or medical treatment.
Q: How long does it last after reconstitution?
A: When stored properly in a sterile vial in refrigeration, it is best used within 20 days.
Q: Do you provide documentation?
A: Yes. Each order includes a Certificate of Analysis and lab-grade reference data for your records.
Q: Can TB500 be shipped internationally?
A: We ship to most countries, but it’s your responsibility to comply with local regulations regarding peptides and research chemicals.
Why Choose Us?
- ✔️ Research-grade quality backed by documentation
- ✔️ Tamper-proof packaging for product integrity
- ✔️ Responsive support from industry-experienced staff
- ✔️ Discreet shipping worldwide
- ✔️ Bulk pricing available for institutions and labs
Order TB500 (5 mg): Research-Grade Peptide
TB500 continues to be one of the most versatile peptides studied for tissue repair, wound healing, and anti-inflammatory research. With reliable quality, detailed documentation, and professional service, we support your lab’s goals every step of the way.
Combine with BPC157 for added benefits: https://www.uksarms.com/product/bpc-157-body-protection-compound-157/
Garcia –
Helped my Achilles Tendonitis
Gonzalez –
The results are amazing! PT people say I’m way ahead of most people that they treat for this surgery. My mobility and rage of motion with the arm is coming back fast. Just bought my second bottle
Lopez –
my injured shoulder is improving
Moore –
They Really Work And Fast Acting
Rodriguez –
I had a severe muscle & tendon injury recently. Well, I think it is helpful, but it could be better. Great value for money
Williams –
Very good product, it worked for me much better than more others. And it’s cheaper too!
King Parker –
I have been taking it for 3 weeks now and am quite stunned at the results. I have had a bum knee for years that kept “Catching”. It felt like a tendon or ligament kept getting stuck. It would eventually let go, but always come back. Since starting this supplement, the catching has completely stopped!! I am truly amazed.
King Parker –
Started doing exercises I normally avoid because of joint pain — it’s been maybe 2 months of that, and I’m still relatively pain-free. TB500 has helped me regain so much mobility, and I’ve recommended it to my coworkers. Highly recommend.
Anderson Smith –
Within a week I noticed the pain and tightness subsiding even though I continued to lap swim at our health club.
Christopher –
Took a dose when it arrived. By the next morning, YES the next morning the pain had decreased. I’ve been getting progressively better EVERY DAY! Today after ONE week, I am at 90% where before I was borderline 50-60% with intermittently good/bad days.
I recommend this product – 100%
Ronald –
TB500 really works, guys. All the best to you if you are on the road to recovery.
Charles Donald –
I purchased this product to see if it would help alleviate some pain in my left Achilles tendon (hurt from overuse), and so far it is helping, actually better than I expected. Usually, I would get up in the morning and I would have some pain in it until I flexed and stretched it to get some blood flow going. I feel a difference. Seems like there is less and less pain in it each day upon waking. I hope it does help heal this area.
Kimberly –
So I highly recommend Acute Injury!
Sharon Laura –
Definitely recommended…just make sure you give it 3-5 weeks to start working effectively.
Nancy –
I didn’t expect much, but it had good reviews and I decided to give it a try. Within the first couple of weeks, my knee felt better. It’s very impressive.
Mary Lisa –
Seems to be helping my hip pain
Patricia –
I think it helped speed up my recovery
Helen –
Knees feel better
Deborah –
Strained my Distal Tendon pretty badly. Continued weight lifting carefully. But was in constant fear and pain for about a month. I came across this and figured why not give it a try. After about 10 days the discomfort was cut in half. Then after about 3 weeks. The discomfort completely disappeared. Just saying its worth a shot.
Margaret –
This product is fantastic! Since taking it for a torn tendon, it has helped me dramatically – both in pain reduction and regaining ability to stand / walk with ever-increasing stability.
Donna –
I HIGHLY recommend this
Dorothy Linda –
I love this product and feel it is the reason my knee is finally better.
Thompson –
Seem to be working
Edwards –
I was having knee and elbow pain for years. After a few months of using Acute Injury I no longer experience any pain from tendons. It’s worth trying it out.
Taylor –
I was suffering from plantar fasciitis for about 4 months, and I was recommended this product from a trusted friend. I could feel a significant improvement the very next day, in the morning, when the pain was usually the worst. In two days my pain was about 80% gone and I was able to put pressure on my foot. I am so grateful for this product. WOW!
Jones Brown –
helped in my shoulder tears healing
Walker Hall –
with tb500 I remain a very active 60-year-old!
Johnson –
Works on chronic knee pain too.
Miller Davis –
It takes a while but my pain is lessening.
Lee –
Packaged nicely and received very fast. Works pretty good for rotator cuff injury
Doug Fiske –
Great product
Allen –
Had a major tear of my Patellar Tendon. Rehab while using this product went better than expected. Am continuing to use!
Young –
Works great for keeping my tendonitis in check so I can continue to work